Selsun Blue is a popular brand of medicated shampoo and lotion that utilizes selenium sulfide as its active ingredient to combat dandruff and related scalp conditions. Selenium sulfide is a topical medicine primarily used to reduce flaking and itching associated with dandruff and seborrheic dermatitis. Additionally, it is effective in treating a fungal skin condition known as tinea versicolor.
Understanding Selenium Sulfide
The mechanism of action for selenium sulfide involves slowing down the growth of skin cells on the surface of the scalp and within hair follicles. This controlled cell turnover helps to alleviate the symptoms of dandruff and other scalp issues.
What Selenium Sulfide is Used For
Selenium sulfide is commonly employed to alleviate the symptoms of dandruff and seborrheic dermatitis, such as flaking and itching. It is also a recognized treatment for tinea versicolor, a fungal infection of the skin. In some instances, a healthcare provider may determine its use for other conditions as well.
Note: The U.S. Food and Drug Administration (FDA) has not found all forms of this medicine to be safe and effective, and the labels for the 2.25% and 2.3% shampoos are not approved by the FDA.

Dosage Forms and Strengths
Selsun Blue products are available in various forms and strengths to cater to different needs:
- Shampoos: Available in 1%, 2.25%, and 2.3% strengths.
- Lotion: Available in a 2.5% strength.
Common brand names and other associated names include:
- Selsun Blue 2-in-1
- Selsun Blue Medicated
- Selsun Blue Moisturizing
- Selsun Blue Normal to Oily
- Dandrex
- Selenos
- SelRx
- Selseb
- Selsun Blue Medicated Treatment
- Tersi Foam
How to Use Selsun Blue
Proper usage is crucial for the effectiveness of Selsun Blue and to minimize potential side effects. Always follow the instructions provided with the product or by your healthcare provider.
Using Selsun Blue for Dandruff or Seborrheic Dermatitis of the Scalp:
- Before applying the medicine, wet your hair and scalp with lukewarm water.
- Apply enough Selsun Blue to create a lather on your scalp. Typically, 1 to 2 teaspoons are sufficient.
- Allow the lather to remain on your scalp for 2 to 3 minutes before rinsing thoroughly.
- Reapply the medicine and rinse well again.
For individuals with light or blond, gray, or chemically treated hair (bleached, tinted, permanent-waved), it is essential to rinse the hair for at least 5 minutes after use to reduce the chance of hair discoloration.
Using Selsun Blue for Tinea Versicolor of the Body:
- Apply the medicine to the affected areas of your body, avoiding the face and genital areas.
- Work up a lather using a small amount of water.
- Allow the medicine to remain on your skin for 10 minutes.
- Rinse your body thoroughly to remove all traces of the medicine.

Important Usage Precautions:
- Do not swallow the medicine. It is for external use only.
- Avoid contact with eyes, lips, and mucous membranes. If accidental contact occurs, rinse thoroughly with water.
- Do not use on broken, red, swollen, or oozing skin unless specifically directed by your doctor.
- Remove jewelry before use, as some products can damage certain types of jewelry.
- Shake the bottle well before each use.
- Follow instructions carefully regarding the amount of time the product should sit on the scalp or skin before rinsing. In some cases, multiple applications may be necessary.
- Rinse thoroughly after use, especially if applied to skin folds or the genital area, to minimize irritation and side effects.
- Wash your hands after treatment.
- Some selenium sulfide shampoos may darken over time; this is normal and does not affect the product's efficacy.
Side Effects and Precautions
While Selsun Blue is generally safe and effective when used as directed, some side effects can occur. It's important to be aware of these and to consult a healthcare provider if you have concerns.
Common Side Effects:
- Skin irritation
- Hair loss
- Discoloration of hair
- Oily or dry hair or scalp
These side effects usually do not require medical attention and may resolve as your body adjusts to the medication. However, if they persist or are bothersome, consult your healthcare professional.
Serious Side Effects:
Though less common, serious allergic reactions can occur. If you experience any of the following symptoms, stop using Selsun Blue immediately and seek medical help:
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Warnings and Precautions:
- Allergies: Do not use if you are allergic to selenium sulfide or any other ingredients in the product.
- Pregnancy and Breastfeeding: It is unknown if selenium sulfide can affect pregnancy or pass into breast milk. Consult your healthcare provider if you are pregnant or breastfeeding.
- Drug Interactions: While no specific interactions with foods, drinks, or other medications are widely known, always inform your healthcare provider about all substances you are using.
- Other Medical Problems: If you have blistered, raw, or oozing areas on your scalp or body, consult your doctor before use, as this may increase the chance of absorption through the skin.
- Children and Elderly: Selsun Blue is generally considered safe for use in children and the elderly, with no expected differences in side effects compared to adults.
- Missed Dose: If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and return to your regular schedule. Do not double doses.
- Monitoring: If your condition does not improve after regular use, or if it worsens, consult your doctor. If a rash or sensitive skin develops, discontinue use.
How Else Can You Use Selsun Blue?
Storage
Store selenium sulfide at room temperature, typically between 68°F to 77°F (20°C to 25°C). While it can tolerate brief exposure to temperatures between 59°F to 86°F (15°C to 30°C), avoid freezing and excessive heat. Keep the medicine in a closed container and out of the reach of children. Do not use outdated or no longer needed medicine.